Design of Experiments (DOE)

Below are some use cases of Isalos Analytics Platform in DOE applications. Each case study is accompanied by:

A Manual User Guide report, providing a detailed, step-by-step description of the methodology and results, and
the corresponding Isalos workflow file, enabling full reproducibility and hands-on execution of the analysis within the platform.

Screening Designs

Opthalmic Drug Delivery System (`Fractional Factorial`)

Arsenic extraction in rice samples (`Plackett Burman`)

Factorial Design

Development of pellets for oral lysozyme delivery (`Full Factorial`)

Development of nanostructured lipid carriers (`Full Factorial`)

Gelling microemulsion of Lorazepam (`Full Factorial`)

Polymeric micelles for cancer treatment (`Full Factorial`)

Response Surface Designs

Formulation of extended release beads (`Box Behnken`)

Development of microsponge based gel (`Box Behnken`)

Formulation of a bi-dependent drug delivery system (`Box Behnken`)

Development of silymarin nanoemulsion (`Box Behnken`)

Development of hydrophilic interaction LC method (`Box Behnken`)

Removal of humic substances using coconut copra (`Central Composite - CCI`)

Biosorption of hexavalent chromium from aqueous media (`Central Composite - CCC`)

Iontophoretic Tacrine Hydrochloride Delivery (`Central Composite - CCF`)

Combination

Bilastine determination by hydrophilic interaction LC (`Box Behnken` & `Fractional Factorial`)

PFAS ENVIRONMENTAL FATE (`Plackett Burman` & `Box Behnken`)

Isalos Publications

Ammonia borane catalytic hydrolysis for H₂ generation (`Box Behnken`)